Irrespective of where people live, socioeconomic conditions, and education, optimal health and well-being should be their right. However, many issues affect health care delivery and increase health inequities. Two major policy issues that affect health care delivery and population health equity are poor access to care and variances in the scope of practice across states. Typically, the access to care problem is multifaceted since provider shortages, high health care costs, implicit bias, and long distances to health care facilities determine when and where people receive health care services (Labban et al., 2023; Lopes et al., 2023). Indeed, these issues widen health disparities and have been at the center of policymaking for a long time. On the other hand, the scope of practice determines the availability of care depending on the authority given to nurses to treat patients and prescribe medications. Nursing research shows that states with full practice authority have a higher prevalence of nurse practitioners, particularly in rural areas (DePriest et al., 2020). The situation differs in reduced and restricted practice states where nurse practitioners are supervised or collaborate with a physician. Addressing these issues through policies and appropriate initiatives is vital for governments and health care providers to reduce health disparities across populations. Population health policies and initiatives centered on addressing access to health problems and scope of authority differences have profound implications on advanced nursing practice. For instance, they require advanced practice nurses to actively participate in policymaking and advocacy to improve care delivery and equity. Such policies also prompt advanced nursing practice nurses to play a pivotal role as change agents in organizations and communities to address barriers to health, including access problems, inequities, and discrimination. As change agents, nurses identify population health problems and implement positive, innovative changes (Cusson et al., 2020). Importantly, nurse practitioners should readily embrace interventions, frameworks, and care delivery models that reduce health care disparities. Achieving this goal requires nurses to integrate a global perspective on health into their routine practice.