The primary role of the Institutional Review Board (IRB) is to provide safety of the human participants and assess the use of animals in a research study (DeNisco, 2021). Generally, research-based studies have safety measure to ensure the safety and rights of the both the human and animal participants are well protected. The members of the IRBs review the scientific validity of the research design and the potential benefits that the study might add. The main ethical concern for the translational research process is the analysis of the risk-benefit ratio. Before embarking on the rigorous research process, an extensive risk-benefit analysis should be conducted in order protect the research subjects and the population from potential harm that may arise as the researchers attempts to satisfy their curiosity (Riva & Petrini, 2019). Second, the issue of informed consent is also a major ethical concern. It is important to work on this issue in order to avoid potential misconceptions. The financial conflicts of interest are an ethical issue likely to be encountered particularly during the preapproval phase of translational research. One of the generally applied safeguards to ensure that the ethical conduct of the research is met is the involvement of external reviewers or the IRBs. Prior to starting the research process, the researchers are required to submit the research proposal that includes the mode of data collection, research advertisements, and informed consent records (Riva & Petrini, 2019). For example, the IRBs might require certain conditions be met. Second, the potential risks to the research subjects must be reduced and the potential benefits must be enhanced.