The ethical challenges faced by translational research depend on the element of the translational process. The various phases of translational research face ethical issues like the biomedical research ethics such as informed consent, animal bioethics, conflicts of interest, social injustice, and risk analysis ethics. The translational gaps confront ethical issues of resource/fund allocation whereas data/information transfer suffer ethical issues with confidentiality of data. (Mandal,et.al 2017) . Ethical guidelines would need to be implemented when conducting translational research. These ethical guidelines should be interesting for research that is more open to social needs, but also for preventing malpractice. In training and career, researchers could benefit from these principles. The researcher should consider 1) Justice, equality, and quality,2) Autonomy and social relevance 3) Responsibility. Researcher should cultivate an environment in which ethics is seen as a positive and integral part of performing research. (López de la Vieja, 2016). As a member of a translational research team, I would make the ethical framework seem relevant for a consistent decision making, notably when the allocation of resources and the assessment of health care are at stake. Requirements such as patients’ needs, including competing needs, fairness, non-discrimination which will create equal chances or equal consideration of them. In general, the research policy must be accountable, and it should integrate the gender perspective, to avoid biases. So, this strategy seems consistent with the legislation concerning research, with ethical principles and governance principles. The integration of research and practices – to bridge real gaps – will require efficiency and additional criteria; for example, it should become more reflexive about possible outcomes, promoting the dialogue with society – as multi-actor exchanges and then, being responsive to agents’ needs. In this sense, responsibility and, in general, ethical principles add value to a model of science connected with public interests (López de la Vieja, 2016). Professional communities should also promote the adoption of standards that lead to ethical conduct, because even physicians themselves might be at risk of serious bias or conflict of interest. An integrated ethical approach that aims for transparency and regulation of development processes, the support of independent judgment and the elimination of unregulated and uncontrolled grey areas of action are necessary (Riva; et al,2019).